If you're an open-source advocate or work with a privacy-conscious team, choose Penpot. Its self-hosting capabilities and adherence to open standards make it ideal for collaborative design projects where control and data security are paramount. However, be prepared for fewer plugins and a bit less polish than you'd find in more established tools like Figma.
On the other hand, if you want to design and publish engaging websites without any coding, Framer is your best bet. It's perfect for designers and founders looking to create marketing sites or portfolios with strong animations and CMS capabilities. However, avoid it if your needs lean towards building complex web applications or you require full control over code and hosting—Framer's limitations in these areas could hinder your project.