For open-source advocates and privacy-conscious teams, Penpot is the clear choice. Its self-hosting capability and reliance on open standards make it ideal for those prioritizing data sovereignty and designer-developer collaboration. However, if you're after a more polished experience with a robust plugin ecosystem, you should steer clear of Penpot, as it doesn't quite match Figma in these areas.
On the other hand, if you need pixel-perfect visual control for web design along with the capability to manage a CMS, Webflow is your best bet. It's perfect for designers and agencies looking to create marketing sites that require rich interactions and clean output. However, be prepared for a steeper learning curve and higher costs as your project scales. Avoid Webflow if you're looking for simplicity or planning to build a complex web app.