If you're an open-source advocate or part of a privacy-conscious team, Penpot is the best choice. It allows for self-hosting and is built on open standards, making it ideal for those who prioritize transparency and control over their design tools. However, be aware that its smaller ecosystem may limit your access to plugins and resources compared to more established options.
On the other hand, if you're a product designer or part of a design team that values robust collaboration, Figma is the way to go. It offers real-time multiplayer design capabilities and a vast library of plugins and community templates. This makes it perfect for teams working on complex projects, though keep in mind that costs can accumulate as team size increases. If you need an offline solution or prefer an open-source model, Figma might not meet your needs.