If you're an open-source advocate or part of a privacy-conscious team, choose Penpot. Its self-hostable nature and compatibility with open standards make it ideal for those who value control and privacy. However, if your project requires a wide range of plugins and a more polished experience, you'll likely find it lacking compared to industry leaders.
On the other hand, if you're a frontend developer or indie hacker working primarily with React and Tailwind, v0 is your go-to tool. It transforms prompts into actual working UI code quickly and integrates seamlessly with modern stacks like Vercel and Next.js. Just be cautious of the credit-based pricing if you plan on heavy usage, and avoid it if you're not in the React/Tailwind ecosystem or need a more comprehensive no-code solution.